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Technology doesn’t grow in isolation—it evolves in waves. Just as mobile, cloud, and SaaS shaped the internet of the past 20 years, so too could crypto, AI, and new hardware usher in an era of the internet that’s pro-innovation, pro-startup, and pro-creator.  Speaking with a16z Growth General Partner David George, a16z crypto Founder and Managing Partner Chris Dixon breaks down his vision for a new internet, from using crypto to decentralize AI infrastructure and kickstart network effects, to why AI will be this era’s native form of media just as film was in the 1930s. He also explores why the internet’s original covenant—where content creators traded free access for search traffic—is breaking today, and how a better internet could introduce entirely new business models for creators.  Right now, we have a choice to make: will the next era of the internet be shaped by a handful of centralized players, or transformed into an open ecosystem where power and control flow to creators across the globe? Resources: Watch the conversation here: https://youtu.be/gioxu1CVjhM   Read more, including the full transcript, here: https://a16z.com/ai-crypto-internet-chris-dixon/ Chris’s recent article on blockchain innovation: https://a16zcrypto.com/posts/article/blockchain-ai-internet/ Find Chris’s book, Read Write Own: Building the Next Era of the Internet: Penguin Random House: https://www.penguinrandomhouse.com/books/744504/read-write-own-by-chris-dixon/ Penguin UK: https://www.penguin.co.uk/books/459860/read-write-own-by-dixon-chris/9781804949245 For more resources on AI & crypto visit: https://a16zcrypto.com/posts/?tag=ai-crypto,web2-to-web3 Stay Updated:  Let us know what you think: https://ratethispodcast.com/a16z Find a16z on Twitter: https://twitter.com/a16z Find a16z on LinkedIn: https://www.linkedin.com/company/a16z Subscribe on your favorite podcast app: https://a16z.simplecast.com/ Follow our host: https://twitter.com/stephsmithio Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its s may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.  

Critical materials like copper, lithium, and gallium have been mined for decades, but their role in core technologies, geopolitics, and the energy transition have come to a height in recent years. In this episode, a16z partner Connie Chan discusses how technology is changing the game of  identification and exploration, together with leading company KoBold and their VP of Geoscience, VP of Technology, and CEO of Africa.   Resources: Learn more about KoBold Metals: https://www.koboldmetals.com/   Stay Updated:  Let us know what you think: https://ratethispodcast.com/a16z Find a16z on Twitter: https://twitter.com/a16z Find a16z on LinkedIn: https://www.linkedin.com/company/a16z Subscribe on your favorite podcast app: https://a16z.simplecast.com/ Follow our host: https://twitter.com/stephsmithio Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its s may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Two words have caught the Internet by storm. DeepSeek.  The Chinese reasoning model r1 is rivaling others at the frontier with an open-source MIT license, methods that some claim may be 45x more efficient, an alleged $5.6m cost, the release of reasoning traces, a follow-on image model, and the fact that all of this was released by a hedge fund China. Many are already referring to this as a Sputnik moment. If that’s true, how should we – whether founder, researcher, policy maker – not just react, but act? ing us to tease out the signal from the noise are a16z General Partner Martin Casado and a16z board partner, Steven Sinofsky. Both Martin and Steven have been on the frontlines of prior computing cycles, from the switching wars to the fiber buildout, and have witnessed the trajectories of companies like Cisco to AOL to ATT – even Worldcom. So what really drove this DeepSeek frenzy and more importantly what should we take away? Today, we answer that question through the lens of Internet history.   Resources: Steven’s article: DeepSeek Has Been Inevitable and Here's Why (History Tells Us) Martin & Ion Stoica’s Economist op-ed: Keep the code behind AI open  Alex Rampell’s article: Why DeepSeek Is a Gift to the American People   Stay Updated:  Let us know what you think: https://ratethispodcast.com/a16z Find a16z on Twitter: https://twitter.com/a16z Find a16z on LinkedIn: https://www.linkedin.com/company/a16z Subscribe on your favorite podcast app: https://a16z.simplecast.com/ Follow our host: https://twitter.com/stephsmithio Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its s may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

This week, a16z cofounder Ben Horowitz had a rare and invaluable conversation with Dr. Clarence B. Jones, a pivotal figure in American history.  Dr. Jones, who served as speechwriter, attorney, and advisor to Dr. Martin Luther King Jr., shared his personal insights on race, inclusion, and the lasting legacy of the civil rights movement in 2025. In their wide-ranging discussion, Dr. Jones reflected on the timeless wisdom of Dr. King, quoting one of the most enduring lines from the "I Have a Dream" speech: “I want my four children to be judged by the content of their character, not by the color of their skin.” “That, to me, is still, that’s the template,” Dr. Jones said. “That still remains a template.” Their conversation covered critical themes in Diversity, Equity, and Inclusion, delving into the history of the movement, the lessons from "Letter from Birmingham Jail," and the profound impact Dr. King’s work continues to have today. It was a rare opportunity to hear directly from someone who not only witnessed history but played a key role in shaping it, and we hope you enjoy it.   About Dr. Clarence B. Jones: Dr. Clarence B. Jones served as legal counsel, strategic advisor, and draft speechwriter to Dr. Martin Luther King, Jr. from 1960 until Dr. King’s assassination in Memphis, Tennessee, on April 4, 1968. During that time, Dr. King depended on Dr. Jones for legal and strategic counsel and assistance in drafting landmark speeches and public testimony. He is credited with writing the first seven paragraphs of the iconic I Have A Dream speech.  Across the decades following Dr. King’s assassination in 1968, Clarence B. Jones worked to carry on Dr. King’s legacy, to continue the nonviolent struggle for social justice, voting rights, and democratic inclusion. He is the founder of the Dr. Clarence B. Jones Institute for Social Advocacy, and also serves as the Founding Director Emeritus of the Institute for Nonviolence and Social Justice at the University of San Francisco. Dr. Jones is also the author of three acclaimed books "What Would Martin Say?", "Behind the Dream: The Making of the Speech that Transformed a Nation" and "Last of the Lions".   Stay Updated:  Let us know what you think: https://ratethispodcast.com/a16z Ben on X:  http://twitter.com/bhorowitz Find a16z on X: https://twitter.com/a16z Find a16z on LinkedIn: https://www.linkedin.com/company/a16z Subscribe on your favorite podcast app: https://a16z.simplecast.com/ Follow our host: https://twitter.com/stephsmithio Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its s may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

How is AI reshaping modern warfare?  Speaking with a16z Growth General Partner David George, Anduril cofounder and CEO Brian Schimpf discusses how AI helps humans make better strategic decisions by sorting through the enormous amount of data collected from modern battlefields. Schimpf also discusses navigating the US government’s complex procurement processes, using commercial technologies to kickstart their own product development, and the growing opportunities for startups in defense. Throughout, Brian offers a deep dive into the intersection of technology, geopolitics, and the future of defense. This episode is part of our AI Revolution series, where we explore how industry leaders are leveraging generative AI to steer innovation and navigate the next major platform shift. Discover more insights and content from the AI Revolution series at a16z.com/AIRevolution.   Resources:  Find Brian on X: https://x.com/schimpfbrian Find David on X: https://x.com/davidgeorge83   Stay Updated:  Let us know what you think: https://ratethispodcast.com/a16z Find a16z on Twitter: https://twitter.com/a16z Find a16z on LinkedIn: https://www.linkedin.com/company/a16z Subscribe on your favorite podcast app: https://a16z.simplecast.com/ Follow our host: https://twitter.com/stephsmithio Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its s may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Intelligent automation is transforming industries by tackling messy, unstructured workflows that traditional Robotic Process Automation (RPA) couldn’t handle. In this episode, a16z partner Kimberly Tan discusses the shift from rigid RPA systems to AI-powered agents and why this evolution unlocks massive opportunities in legacy markets. Drawing on her article "RIP to RPA: The Rise of Intelligent Automation," Kimberly shares real-world examples of companies revolutionizing referral management, and highlights how startups can build impactful solutions in this space. Resources: Find Kimberly on X: https://x.com/kimberlywtan Read Kimberly’s article: https://a16z.com/rip-to-rpa-the-rise-of-intelligent-automation/ Stay Updated:  Let us know what you think: https://ratethispodcast.com/a16z Find a16z on Twitter: https://twitter.com/a16z Find a16z on LinkedIn: https://www.linkedin.com/company/a16z Subscribe on your favorite podcast app: https://a16z.simplecast.com/ Follow our host: https://twitter.com/stephsmithio Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its s may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Healthcare is a $4 trillion industry, making up nearly a fifth of the U.S. economy—but despite having some of the best doctors and advanced technology, the system often delivers poor outcomes at skyrocketing costs. Why is this the case, and what will it take to fix it? In this episode, a16z cofounder Marc Andreessen and General Partners Vijay Pande and Julie Yoo tackle some of the biggest questions shaping the future of healthcare: Is the solution to our healthcare crisis a policy, technology, or competition problem? Will AI and technology transform the industry, or are regulatory and structural barriers too entrenched? Who will crack the code—healthcare incumbents, tech giants, or AI-native startups? From chronic care to cost curves, from disruptive technologies to shifting patient agency, this conversation offers an unfiltered look at what’s broken in the healthcare system and how it might finally change. Resources:  Find Marc on X: https://x.com/pmarca Find Vijay on X: https://x.com/vijaypande Find Julie on X: https://x.com/julesyoo The Biggest Company in the World Why Will Healthcare be the Industry that Benefits Most from AI? Grand Challenges in Healthcare AI with Vijay Pande and Julie Yoo Stay Updated:  Let us know what you think: https://ratethispodcast.com/a16z Find a16z on Twitter: https://twitter.com/a16z Find a16z on LinkedIn: https://www.linkedin.com/company/a16z Subscribe on your favorite podcast app: https://a16z.simplecast.com/ Follow our host: https://twitter.com/stephsmithio Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its s may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Email, a technology from 1971, is powering one of today’s most disruptive media platforms. In this episode, Substack cofounder and CEO Chris Best s a16z General Partner Andrew Chen to discuss the origins and evolution of Substack, a platform redefining media and empowering creators to connect directly with their audiences. They dive into how Substack’s early days led to over 3 million paid subscribers, why creators are moving away from traditional platforms to establish direct connections with their audiences, and how the future of media in the AI era is reshaping opportunities for writers, podcasters, and video creators. From Chris’s lessons scaling Kik Messaging to Substack’s profound impact on the creator economy, this conversation shares insights on building platforms, culture, and opportunity in the modern era.   Resources:  Find Chris on Substack: https://cb.substack.com/ Find Andrew Chen on Substack: https://andrewchen.substack.com/   Stay Updated:  Let us know what you think: https://ratethispodcast.com/a16z Find a16z on Twitter: https://twitter.com/a16z Find a16z on LinkedIn: https://www.linkedin.com/company/a16z Subscribe on your favorite podcast app: https://a16z.simplecast.com/ Follow our host: https://twitter.com/stephsmithio Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its s may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

with @sambroner @meigga @darenmatsuoka @jneu_net @chrislyons and @rhhackett @smc90 Welcome to our special end-of-year episodes -- which also look ahead to 2025 --  covering our annual Big Ideas lists, where various a16z crypto team share what they are personally excited about. (You can see the firmwide list, also including all the trends of the crypto team,  here.) This episode is part 1 of 2 -- but you don't have to listen to them in any particular order -- covering the trends and themes of: stablecoins, payments, and where the early adopters will come from; app store distribution, curation, and discovery; where the next crypto s will come from, turning ive holders into active s; how builders improve, and better choose, infrastructure; and simplifying experience.  Covering each of these -- and coming from the investing, go-to-market, data science, research, and media teams are:  Sam Broner, Maggie Hsu, Daren Matsuoka, Joachim Neu, and Chris Lyons; in conversation with hosts Sonal Chokshi and Robert Hackett. (Stay tuned until the end for some of our meta-commentary.)  These are just 5 of the 14 trends we shared; you can check out the full list at a16zcrypto.com/bigideas. Also be sure to check out part 2, which covers all the trends at the intersection of crypto and AI.  As a reminder, none of the content is investment, business, legal, or tax advice; please see a16z.com/disclosures for more important information -- including a link to a list of our investments.

As we prepare to step into 2025, the possibilities for applied AI are reshaping industries in profound ways.  In this episode, a16z General Partners Julie Yoo and Angela Strange, and Partner Joe Schmidt, dive into the transformative power of AI across healthcare, fintech, and traditional service sectors. We explore: Super Staffing for Healthcare: How AI can address critical clinical labor shortages and augment care delivery at scale. Regulation Becomes Code: The potential for AI to simplify and streamline compliance, making systems safer and more efficient. Romanticizing Inorganic Growth: The opportunity for AI-powered startups to redefine service industries through workflow automation and strategic acquisition. With insights from a16z’s Bio + Health, Fintech, and Apps teams, this episode unpacks the ideas that will revolutionize traditional systems and unlock opportunities in 2025. Check out the full 50 Big Ideas for 2025 at a16z.com/bigideas.   Resources:  Find Angela on X: https://x.com/astrange Find Julie on X: https://x.com/julesyoo Find Joe on X: https://x.com/joeschmidtiv Link to article 'The Messy Inbox Problem: Wedge Strategies in AI Apps': https://a16z.com/the-messy-inbox-problem-ai-apps-wedge-strategies   Stay Updated:  Let us know what you think: https://ratethispodcast.com/a16z Find a16z on Twitter: https://twitter.com/a16z Find a16z on LinkedIn: https://www.linkedin.com/company/a16z Subscribe on your favorite podcast app: https://a16z.simplecast.com/ Follow our host: https://twitter.com/stephsmithio Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its s may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

The AI race is on, and 2025 could be its most transformative year yet. In this episode, a16z General Partners Anjney Midha and Jennifer Li, and Partner Alex Immerman dive into the trends reshaping AI and its impact on search, infrastructure, and devices. We explore: How AI-native tools like ChatGPT and Perplexity are challenging Google’s search dominance. The rise of infrastructure independence as governments prioritize compute, energy, and data. The future of smaller, on-device AI models driving privacy, performance, and new consumer applications. With insights from a16z’s Growth and Infrastructure teams, this episode unpacks the forces driving AI innovation—and the opportunities founders and nations could seize to lead in the next wave of technology. Stay tuned for more in this four-part series, and explore the full 50 Big Ideas for 2025 at a16z.com/bigideas. Resources:  Find Alex on X: https://x.com/aleximm FInd Anjney on X: https://x.com/AnjneyMidha FInd Jennifer on X: https://x.com/JenniferHli Stay Updated:  Let us know what you think: https://ratethispodcast.com/a16z Find a16z on Twitter: https://twitter.com/a16z Find a16z on LinkedIn: https://www.linkedin.com/company/a16z Subscribe on your favorite podcast app: https://a16z.simplecast.com/ Follow our host: https://twitter.com/stephsmithio Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its s may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

As 2025 begins, industries are evolving at unprecedented speed: robots are revolutionizing manufacturing, terabytes of earth observation data are driving new possibilities, and gaming technology is transforming how we design, train, and innovate across sectors. In this episode, a16z General Partner Erin Price-Wright, Engineering Fellow Millen Anand, and Partner Troy Kirwin discuss the trends reshaping the future of hardware, software, and beyond. We explore: How robots and full-stack engineers are driving the next industrial renaissance. The explosion of Earth observation data and its potential to revolutionize industries. How gaming technology is moving beyond entertainment to reshape training, design, and more. This is just the beginning of our four-part series on 50 Big Ideas for 2025—don’t miss the full list at a16z.com/bigideas. Resources:  Find Erin on X: https://x.com/espricewright Find Millen on LinkedIn: https://www.linkedin.com/in/millen-anand/ Find Troy on X: https://x.com/tkexpress11 Stay Updated:  Let us know what you think: https://ratethispodcast.com/a16z Find a16z on Twitter: https://twitter.com/a16z Find a16z on LinkedIn: https://www.linkedin.com/company/a16z Subscribe on your favorite podcast app: https://a16z.simplecast.com/ Follow our host: https://twitter.com/stephsmithio Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its s may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

In this episode of Web3 with a16z, Shopify CEO and cofounder Tobias Lütke s a16z cofounder Ben Horowitz for a conversation recorded live at the a16z crypto Founders Summit. Together, they explore what it takes to build a breakout startup in a competitive market, the changing landscape of retail, and how to drive workplace change while navigating corporate culture and calls for activism. Tobias shares the story behind Shopify's growth from a snowboarding store to a global ecommerce platform serving millions of merchants, discusses the moral imperative of creating great software, and offers insights on leadership, innovation, and embracing negativity as a tool for progress. The episode also touches on the intersection of AI and crypto, the power of decentralization, and the next wave of technologies reshaping business and commerce.   Resources: Find Ben on X: https://x.com/bhorowitz Find Toni on X: https://x.com/tobi   Stay Updated:  Let us know what you think: https://ratethispodcast.com/a16z Find a16z on Twitter: https://twitter.com/a16z Find a16z on LinkedIn: https://www.linkedin.com/company/a16z Subscribe on your favorite podcast app: https://a16z.simplecast.com/ Follow our host: https://twitter.com/stephsmithio Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its s may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Did you know the U.S. nurse labor market is over $600 billion annually, but the dedicated software market for nurses is almost zero? In this episode General Partners Alex Rampell, David Haber, and Angela Strange discuss how AI is revolutionizing labor by automating tasks traditionally done by humans. They’ll trace the evolution of cloud eras — from the original to financial services-enabled to the current AI-enabled outcomes era — showcasing how AI is creating unprecedented opportunities, allowing startups to outpace incumbents. They also explore how this shift will reshape industries, where we are in the adoption curve and what companies need to succeed, and the gaps where the a16z Enterprise team would love to see more innovation. Resources: AI Turns Capital to Labor:  https://a16z.com/ai-turns-capital-to-labor/ The Messy Inbox Problem:  https://a16z.com/the-messy-inbox-problem-ai-apps-wedge-strategies/ Vertical SaaS: Now with AI Inside: https://a16z.com/vertical-saas-now-with-ai-inside/ BarbAIrians at the Gate: The Financial Opportunity of AI:  https://a16z.com/financial-opportunity-of-ai/Stay Updated:  Let us know what you think: https://ratethispodcast.com/a16z Find a16z on Twitter: https://twitter.com/a16z Find a16z on LinkedIn: https://www.linkedin.com/company/a16z Subscribe on your favorite podcast app: https://a16z.simplecast.com/ Follow our host: https://twitter.com/stephsmithio Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its s may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.a  

Over half of Americans live in childcare deserts, while 90% of brain development happens before the age of five. All the while, education and childcare remain among the most resistant sectors to technological change. Billions of dollars have been spent, but outcomes continue to lag. Why? In this episode, we dive into the systemic issues—misaligned incentives, political resistance, and the lack of a shared vision around the purchase of an education. We also explore how technology and entrepreneurial innovation may be shifting the tide. You’ll hear from Anurupa Ganguly (Prisms), Chris Bennett (Wonderschool), Anna Edwards (Whiteboard Advisors), and a16z General Partner Jeff Jordan discuss the criticality of early childhood education, how public-private partnerships are required for scale, and how we can engage risk-averse decision-makers.  Listen to learn how the next generation can reclaim the American dream.   Resources:  Find Jeff on Twitter: https://x.com/jeff_jordan Find Chris on Twitter: https://x.com/8ennett Find Anna on LinkedIn: https://www.linkedin.com/in/annakimseyedwards/ Find Anurupa on Twitter: https://x.com/aganguly26   Stay Updated:  Let us know what you think: https://ratethispodcast.com/a16z Find a16z on Twitter: https://twitter.com/a16z Find a16z on LinkedIn: https://www.linkedin.com/company/a16z Subscribe on your favorite podcast app: https://a16z.simplecast.com/ Follow our host: https://twitter.com/stephsmithio Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its s may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

This episode was originally published on our sister podcast, web3 with a16z. If you’re excited about the next generation of the internet, check out the show: https://link.chtbl.com/hrr_h-XC We've heard a lot about the premise and the promise of prediction markets for a long time, but they finally hit the main stage with the most recent election. So what worked (and didn't) this time? Are they really better than pollsters, is polling dead?  So in this conversation, we tease apart the hype from the reality of prediction markets, from the recent election to market foundations... going more deeply into the how, why, and where these markets work. We also discuss the design challenges and opportunities (including implications for builders throughout). And we also cover other information aggregation mechanisms -- from peer prediction to others -- given that prediction markets are part of a broader category of information-elicitation and information-aggregation mechanisms.  Where do domain experts, superforecasters, pollsters, and journalists come in (and out)? Where do (and don't) blockchain and crypto technologies come in -- and what specific features (decentralization, transparency, real-time, open source, etc.) matter most, and in what contexts?  Finally, we discuss applications for prediction and decision markets -- things we could do right away to in the near-future to sci-fi -- touching on trends like futarchy, AI entering the market, DeSci, and more.   Our special expert guests are Alex Taborrok, professor of economics at George Mason University and Chair in Economics at the Mercatus Center; and Scott Duke Kominers, research partner at a16z crypto, and professor at Harvard Business School  -- both in conversation with Sonal Chokshi.  As a reminder: None of the following should be taken as business, investment, legal, or tax advice; please see a16z.com/disclosures for more important information.    Resources: (from links to research mentioned to more on the topics discussed) The Use of Knowledge in Society by Friedrich Hayek (American Economic Review, 1945) Everything is priced in by rsd99 (r/wallstreetbets, 2019) Idea Futures (aka prediction markets, information markets) by Robin Hanson (1996) Auctions: The Social Construction of Value  by Charles Smith Social value of public information by Stephen Morris and Hyun Song Shin (American Economic Review, December 2002) Using prediction markets to estimate the reproducibility of scientific research by Anna Dreber, Thomas Pfeiffer, Johan Almenberg, Siri Isaksson, Brad Wilson, Yiling Chen, Brian Nosek, and Magnus Johannesson (Proceedings of the National Academy of Sciences (November 2015) A solution to the single-question crowd wisdom problem by Dražen Prelec, Sebastian Seung, and John McCoy (Nature, January 2017) Targeting high ability entrepreneurs using community information: Mechanism design in the field by Reshmaan Hussam, Natalia Rigol, and Benjamin Roth (American Economic Review, March 2022) Information aggregation mechanisms: concept, design, and implementation for a sales forecasting problem by Charles Plott and Kay-Yut Chen, Hewlett Packard Laboratories (March 2002) If I had a million [on deciding to dump the CEO or not] by Robin Hanson (2008) Futarchy: Vote values, but bet beliefs by Robin Hanson (2013) From prediction markets to info finance by Vitalik Buterin (November 2024) Composability is innovation by Linda Xie (June 2021) Composability is to software as compounding interest is to finance by Chris Dixon (October 2021) resources & research on DAOs, a16z crypto   Stay Updated:  Let us know what you think: https://ratethispodcast.com/a16z Find a16z on Twitter: https://twitter.com/a16z Find a16z on LinkedIn: https://www.linkedin.com/company/a16z Subscribe on your favorite podcast app: https://a16z.simplecast.com/ Follow our host: https://twitter.com/stephsmithio Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its s may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

Sales is evolving. AI-native systems are replacing traditional CRM tools, capturing unstructured insights from emails, Slack, surveys, and more in real time. These systems automate early-stage tasks like prospecting and qualification, enabling sales teams to focus on high-value work—while AI provides live coaching and drives decisions across sales, marketing, and product teams. In this episode, a16z partners Joe Schmidt and Marc Andrusko explore the evolution of sales tools and strategies, sharing their insights on what’s driving this shift. Is this the “Death of a Salesforce”? Perhaps that’s an overstatement. But one thing is clear: the future belongs to those who leverage data and AI to drive decisions—not just activities.   Resources: Find Marc Andrusko on X: https://x.com/mandrusko1 Find Joe Schmidt on X: https://x.com/joeschmidtiv Read the original article: https://a16z.com/ai-transforms-sales/   Stay Updated:  Let us know what you think: https://ratethispodcast.com/a16z Find a16z on Twitter: https://twitter.com/a16z Find a16z on LinkedIn: https://www.linkedin.com/company/a16z Subscribe on your favorite podcast app: https://a16z.simplecast.com/ Follow our host: https://twitter.com/stephsmithio Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its s may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

What if the biggest challenge of our time isn’t living longer, but living better?  In this episode, we’re tackling one of humanity’s greatest accomplishments—and perhaps its most overlooked challenge: longevity. As more people live past 100, our systems—healthcare, finance, career planning, and even our cultural perceptions of aging—need a fundamental overhaul.  We’re ed by Dr. Andrew Scott, author of The Longevity Imperative, and Vijay Pande a16z’s Bio & Health general partner, to explore how a shift from “sick care” to “health care” could transform our lives. Together, we discuss the implications of longer lifespans, from the individual choices that can improve our healthspans to the economic and societal shifts required to sustain a healthier, more productive aging society.  us as we reimagine the future of aging, where living to 100 can be more than survival—it can be a life well-lived.   Resources:  Find Andrew on X: https://x.com/profandrewscott?lang=en Find Vijay on X: https://x.com/vijaypande Learn more about The Longevity Imperative: https://profandrewjscott.com/the-longevity-imperative/   Stay Updated:  Let us know what you think: https://ratethispodcast.com/a16z Find a16z on Twitter: https://twitter.com/a16z Find a16z on LinkedIn: https://www.linkedin.com/company/a16z Subscribe on your favorite podcast app: https://a16z.simplecast.com/ Follow our host: https://twitter.com/stephsmithio Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its s may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

America is a country of immense wealth, but our manufacturing infrastructure is struggling to keep pace. In this episode, we discuss the overlooked crisis of American manufacturing and what it means for our national resilience. a16z’s Oliver Hsu hosts a conversation with founders Jordan Black (Senra Systems), Chris Power (Hadrian), and Bryon Hargis (Castellan) on why we need to revive our industrial base — and fast. From outdated regulations to the adoption of automation, they break down the “death by a thousand paper cuts” that has left our production capabilities lagging behind. Yet, it’s not all grim: these founders share how their companies are taking bold, vertically integrated approaches to reinvent the sector and reclaim America's industrial edge.   Resources: Find Chris on X: https://x.com/2112Power Find Jordan on X: https://x.com/jordan__black Find Bryon on X: https://x.com/hargsb Find Oliver on X: https://x.com/oyhsu   Stay Updated:  Let us know what you think: https://ratethispodcast.com/a16z Find a16z on Twitter: https://twitter.com/a16z Find a16z on LinkedIn: https://www.linkedin.com/company/a16z Subscribe on your favorite podcast app: https://a16z.simplecast.com/ Follow our host: https://twitter.com/stephsmithio Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its s may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.

2024 has been a milestone year for autonomous tech.  Waymo’s fully autonomous driver has sured 20 million miles, while FAA approvals now allow commercial drones to fly without visual observers, advancing air autonomy in unprecedented ways. In this special live recording from SF Tech Week, a16z partner Erin Price-Wright moderates a of experts from three key domains—air, land, and sea—to explore the latest real-world deployments of autonomous systems, the impact of new chips on cost and efficiency, building full-stack solutions, managing risk, and the evolving role of regulation in driving these technologies forward. ing the conversation is Macario Namie, CMO of Skydio, discussing the transition from consumer drones to enterprise and government use; Vijay Patnaik, Head of Product at Applied Intuition, who shares insights on developer tools and software for autonomous vehicles; and Peter Bowman-Davis, engineering fellow at a16z, diving into maritime autonomy based on his work at Saronic.   Resources:  Find Macario on LinkedIn: https://www.linkedin.com/in/macario-namie-bb529/ Find Vijay on LinkedIn: https://www.linkedin.com/in/vijaysaipatnaik/ Find Peter on LinkedIn: https://www.linkedin.com/in/peter-bowman-davis/ Find Erin on Twitter: https://x.com/espricewright   Stay Updated:  Let us know what you think: https://ratethispodcast.com/a16z Find a16z on Twitter: https://twitter.com/a16z Find a16z on LinkedIn: https://www.linkedin.com/company/a16z Subscribe on your favorite podcast app: https://a16z.simplecast.com/ Follow our host: https://twitter.com/stephsmithio Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its s may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.